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… of secondary metabolism. Welcome back. This will be episode 12 of Natural Prodcast. And it’s our conversation with … Europe. So if there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And …

… materials. The proposal submission deadline is March 31, 2026 .  … (CMMs). Click for a list of CMMs and the results of the 2023 DOE Critical Materials Assessment . While we expect most … the Molecular Foundry, the project needs to be scoped for 12 months or less. We can help you scope that part of the …

… as well as a unique opportunity to complete a California K-12 science or math teaching credential as an undergraduate …

… there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re … happening. And so we should have somewhere around 10, 11, 12 million BGCs in the database on the release, and that’s … Metabolites Collaboratory SMC Workshop Materials from the 2023 JGI Annual Meeting Using the SMC Website API Endpoints …

… right? BEN: Yeah, yeah. Well, we are at [10 to the] minus 12 [Molar concentration]- is sufficient to kill cells. So … So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain …

… in Yu et al, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 1253–1262, 70:3 ALISON TAKEMURA: And so did you succeed in … Catalog of Earth’s Microbiomes. Nature  Biotechnology . 2020 Nov 9. doi: 10.1038/s41587-020-0718-6) DAN UDWARY: Yeah, … Microbiomes” paper is here . Read the associated JGI news release here . Software we discussed, used for genome …

… list available at Google Scholar. Dutkiewicz, Z. et al (2025) “ Proposal of Patescibacterium danicum gen. nov., sp. … Communications , Volume 5 Issue 1. Wittmers, F. et al (2024) “ Non-photosynthetic lineages sibling to Cyanobacteria … Issue 22. Krinos, A.I., Mars Brisbin, M., Hu, S.K. et al. (2024) “ Missing microbial eukaryotes and misleading meta-omic …

… Coclet C, Camargo AP, Roux S. (2024) MVP: a modular viromics pipeline to identify, filter, … from metagenomes. mSystems 9:e00888-24. https://doi.org/10.1128/msystems.00888-24 Coclet, C., Sorensen, P.O., Karaoz, U. … of hypermutation in the global microbiome. Nat Commun 12, 3076. https://doi.org/10.1038/s41467-021-23402-7 Roux, …

… access to the whole sigma catalog of precursors in their 12C form. You can feed those and look for incorporation in … would grow up our bacteria on 13C methane or methanol, feed 12C methionine, and we were able to pull out the quorum … source and the other with 13C carbon source plus your 12C precursor. You look for a shift of four. Boom. It works …

… 10 to the negative 9th. Picomolar, 10 to the negative 12th. DAN: Yeah. So very-- BETSY PARKINSON: Very, very-- … the issues is in order to make the tetrapeptide, that's a 12 membered ring. And there's extreme ring strain in 12 membered rings. You also have to change the amide …